EA 3221, FR CNRS 3038


Informations

DIRECTEUR :
Adam DAICH
Mél : adam.daich@univ-lehavre.fr

DIRECTEUR ADJOINT :
Michel GRISEL
Mél : michel.grisel@univ-lehavre.fr

SECRÉTARIAT :
Valerie Guyot
Horaires :
Du Lundi au Vendredi de
8h30-12 h30 / 13h30-17h00
Téléphone : 02 32 74 43 96
Mél : urcom@univ-lehavre.fr

ADRESSE POSTALE :
Université du Havre
URCOM
25, rue Philippe Lebon
BP 1123
76063 Le Havre cedex
France

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PhD in Organic Chemistry – Alkyne and cationic Chemistry/mixed Organo-metallocatalysis

par Valérie GUYOT - publié le

“Developments in alkynyl group transfers through a gold-silicon synergetic catalysis strategy”

Key words : Alkyne chemistry, gold catalysis, silylium catalysis, synergetic effects, cascade reactions.


This PhD project aims at expanding the synthetic applicability of a new concept recently developed in our team for the alkynyl group transfer to pro-electrophiles through a synergetic gold-silicon association (TMS-alkynes and LAuX catalyst)[references (a) and (b)]. New and original pro-electrophiles of completely different structures are planned to be investigated so as to probe the potential of the method in the widest way. Opportunities in cascading the alkynyl transfer events with other catalytic processes to rapidly reach molecular complexity in a sustainable fashion will also be explored.
Mechanistic studies towards rationalizing some unexpected and spectacular effects observed recently will be part of the PhD program. Finally, during the course of the thesis there will be collaborative possibilities with the team of Pr. Patrick Pale in LASYROC (Laboratoire de Synthèse Organique, réactivité et Catalyse - University of Strasbourg).

Recent publications :

(a) M. Michalska ; O. Songis ; S. Bew ; C. Taillier ; V. Dalla Adv. Synth. Catal. 2014, 356, 2040 ;
(b) M. Berthet ; O. Songis ; C. Taillier ; V. Dalla J. Org. Chem. 2017, 82, 9916 ;
(c) B. Touati ; A. El Bouakher ; M. S. Azizi ; C. Taillier ; R. Ben Othman ; M. Trabelsi-Ayadi ; S. Antoniotti ; E. Dunach ; V. Dalla Eur. J. Org. Chem. 2017, 4445.
(d) M. Berthet ; A. Beauseigneur ; C. Moine ; C. Taillier ; M. Othman ; V. Dalla Chem. Eur. J. 2018, 24, 1278 ;

Offer type : Ph-D

Funding : French Government Allocation

Salary : ca .1400 € netto/month

Recruiting organization : Université Le Havre Normandie (ULHN)

Workplace : Le Havre (76) - France

Skill area : Chemistry – Organic chemistry

Starting date : October, 1st 2019

Candidate Profile :

The candidate should hold a master degree in organic chemistry at the start of the position. He/She should have a strong background in organic synthesis and characterization methods (NMR, GC, MS, HPLC, etc). An experience in catalysis and/or handling of sensitive compounds under inert atmosphere will be appreciated.
The expected qualities of the candidate are high motivation for research, a good organization in his/her work, ability to integrate easily and to communicate, independency in research work.
To apply, please send a detailed CV, a cover letter, academic transcripts and rankings of the past two years and contact details of two referents before September, 15th 2019.

Contacts :

Vincent.dalla@univ-lehavre.fr
Catherine.taillier@univ-lehavre.fr